Stability Implications of Repackaging Paracetamol Tablets into Dose Administration Aids

Stability Implications of Repackaging Paracetamol Tablets into Dose Administration Aids

Background: Despite the widespread use of dose administration aids (DAAs) there is little available data on the stability of drugs during repackaging or storage in these devices. Aim: To investigate the physicochemical stability of paracetamol tablets repackaged in DAAs. Method: Physicochemical stability studies were performed on a commonly used paracetamol tablet directly after heat-sealing in...

Stability of paracetamol tablets repackaged in dose administration aids for prn use: Implications for practice

Stability of Frusemide Tablets Repackaged in Dose Administration Aids

Background: Repackaging tablets into a dose administration aid (DAA) requires that the pharmacist consider the stability of the active pharmaceutical ingredient and the excipients of the drug product. Frusemide is susceptible to photodegradation and is commonly repackaged into DAAs. Aim: To evaluate the stability (chemical and physical) of frusemide tablets repackaged into DAAs. Method: Frusemi...

Prochlorperazine tablets repackaged into dose administration aids: can the patient be assured of quality?

BACKGROUND AND OBJECTIVE Patients are increasingly requiring their medications to be repackaged into dose administration aids because of the positive outcomes associated with reduction in medication related hospitalization and adverse effects due to improved medicines management. Since the stability of these repackaged medications is not the responsibility of manufacturer, it is important that ...

Stability of medicines after repackaging into multicompartment compliance aids: eight criteria for detection of visual alteration

INTRODUCTION Multicompartment compliance aids (MCA) are widely used by patients. They support the management of medication and reduce unintentional nonadherence. MCA are filled with medicines unpacked from their original packaging. Swiss pharmacists currently provide MCA for 1-2 weeks, although little and controversial information exists on the stability of repackaged medicines. OBJECTIVE We ...